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Figure 3. Effect of BAY-293 on the KRAS/SOS-1 pathway in 8305C cells. The blots revealed a significant modulation of KRAS/SOS-1 marker expression following BAY-293 treatment. BAY-293 at concentrations of 1 µM, 10 µM, and 25 µM was able to significantly reduce the expression of son of sevenless 1 (SOS-1) (A), see densitometric analysis panel (A1) and β-catenin (B), see densitometric analysis panel (B1) compared to untreated 8305C cells. At concentrations of 10 µM and 25 µM, BAY-293 significantly reduced phosphorylated <t>p38</t> mitogen-activated <t>protein</t> <t>kinase</t> <t>(p38</t> <t>MAPK)</t> (D), see densitometric analysis panel (D1) levels compared to untreated cells, while only the highest concentrations of 25 µM was able to significantly reduce extracellular signal-regulated kinase (p-ERK) levels (E), see densitometric analysis panel (E1). Treatment with BAY-293 (10 µM and 25 µM) was also able to increase the expression of tumor suppressor protein phosphatase and tensin homolog (PTEN) (C), see densitometric analysis panel (C1). *** p < 0.001 vs. control (CTR); ** p < 0.01 vs. CTR; * p < 0.05. Our data are the result of three experimental replicates. Data are representative of at least three independent experiments. Values are means ± SDs. We used one-way ANOVA tests followed by Bonferroni post hoc tests for multiple comparisons.
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Figure 3. Effect of BAY-293 on the KRAS/SOS-1 pathway in 8305C cells. The blots revealed a significant modulation of KRAS/SOS-1 marker expression following BAY-293 treatment. BAY-293 at concentrations of 1 µM, 10 µM, and 25 µM was able to significantly reduce the expression of son of sevenless 1 (SOS-1) (A), see densitometric analysis panel (A1) and β-catenin (B), see densitometric analysis panel (B1) compared to untreated 8305C cells. At concentrations of 10 µM and 25 µM, BAY-293 significantly reduced phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) (D), see densitometric analysis panel (D1) levels compared to untreated cells, while only the highest concentrations of 25 µM was able to significantly reduce extracellular signal-regulated kinase (p-ERK) levels (E), see densitometric analysis panel (E1). Treatment with BAY-293 (10 µM and 25 µM) was also able to increase the expression of tumor suppressor protein phosphatase and tensin homolog (PTEN) (C), see densitometric analysis panel (C1). *** p < 0.001 vs. control (CTR); ** p < 0.01 vs. CTR; * p < 0.05. Our data are the result of three experimental replicates. Data are representative of at least three independent experiments. Values are means ± SDs. We used one-way ANOVA tests followed by Bonferroni post hoc tests for multiple comparisons.

Journal: International journal of molecular sciences

Article Title: KRAS-SOS-1 Inhibition as New Pharmacological Target to Counteract Anaplastic Thyroid Carcinoma (ATC).

doi: 10.3390/ijms26062579

Figure Lengend Snippet: Figure 3. Effect of BAY-293 on the KRAS/SOS-1 pathway in 8305C cells. The blots revealed a significant modulation of KRAS/SOS-1 marker expression following BAY-293 treatment. BAY-293 at concentrations of 1 µM, 10 µM, and 25 µM was able to significantly reduce the expression of son of sevenless 1 (SOS-1) (A), see densitometric analysis panel (A1) and β-catenin (B), see densitometric analysis panel (B1) compared to untreated 8305C cells. At concentrations of 10 µM and 25 µM, BAY-293 significantly reduced phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) (D), see densitometric analysis panel (D1) levels compared to untreated cells, while only the highest concentrations of 25 µM was able to significantly reduce extracellular signal-regulated kinase (p-ERK) levels (E), see densitometric analysis panel (E1). Treatment with BAY-293 (10 µM and 25 µM) was also able to increase the expression of tumor suppressor protein phosphatase and tensin homolog (PTEN) (C), see densitometric analysis panel (C1). *** p < 0.001 vs. control (CTR); ** p < 0.01 vs. CTR; * p < 0.05. Our data are the result of three experimental replicates. Data are representative of at least three independent experiments. Values are means ± SDs. We used one-way ANOVA tests followed by Bonferroni post hoc tests for multiple comparisons.

Article Snippet: Anti-PTEN (1:500; sc7974; Santa Cruz Biotechnology, Dallas, TX, USA), anti-SOS-1 (1:500; sc-17793; Santa Cruz Biotechnology), anti-p-p38 MAPK (1:500; sc-166182, Santa Cruz Biotechnology), anti-pERK (1:500; sc-7383; Santa Cruz Biotechnology), p38 MAPK (1:500; sc-7972; Santa Cruz Biotechnology), ERK (1:500; sc-514302; Santa Cruz Biotechnology), β-catenin (1: 500; sc7963; Santa Cruz Biotechnology), anti-BID (1:500; sc-11423; Santa Cruz Biotechnology), anti-BAX (1:500; sc-20067; Santa Cruz Biotechnology), and anti-p53 (1:500; sc-126; Santa Cruz Biotechnology,) were the primary antibodies utilized.

Techniques: Marker, Expressing, Control

Figure 7. Effect of BAY-293 on the KRAS/SOS-1 pathway in an orthotopic model of ATC. The blots revealed a significant reduction in son of sevenless 1 (SOS-1) after treatment with BAY-293 at the doses of 10 mg/kg and 50 mg/kg compared to sham mice (A), densitometric analysis panel (A1). BAY-293 significantly reduced β-catenin levels (B), densitometric analysis panel (B1) and phosphorylated extracellular signal-regulated kinase (p-ERK) levels (D), densitometric analysis panel (D1) at doses of 10 mg/kg and 50 mg/kg compared to ATC mice. Only the highest dose of 50 mg/kg of BAY-293 was able to significantly reduce the expression of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) (C), densitometric analysis panel (C1) compared to the ATC group. Values are means ± SDs. Distribution of values come from individual animals. One-way ANOVA test. *** p < 0.001 vs. sham; ## p < 0.01 vs. ATC; ### p < 0.001 vs. ATC.

Journal: International journal of molecular sciences

Article Title: KRAS-SOS-1 Inhibition as New Pharmacological Target to Counteract Anaplastic Thyroid Carcinoma (ATC).

doi: 10.3390/ijms26062579

Figure Lengend Snippet: Figure 7. Effect of BAY-293 on the KRAS/SOS-1 pathway in an orthotopic model of ATC. The blots revealed a significant reduction in son of sevenless 1 (SOS-1) after treatment with BAY-293 at the doses of 10 mg/kg and 50 mg/kg compared to sham mice (A), densitometric analysis panel (A1). BAY-293 significantly reduced β-catenin levels (B), densitometric analysis panel (B1) and phosphorylated extracellular signal-regulated kinase (p-ERK) levels (D), densitometric analysis panel (D1) at doses of 10 mg/kg and 50 mg/kg compared to ATC mice. Only the highest dose of 50 mg/kg of BAY-293 was able to significantly reduce the expression of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) (C), densitometric analysis panel (C1) compared to the ATC group. Values are means ± SDs. Distribution of values come from individual animals. One-way ANOVA test. *** p < 0.001 vs. sham; ## p < 0.01 vs. ATC; ### p < 0.001 vs. ATC.

Article Snippet: Anti-PTEN (1:500; sc7974; Santa Cruz Biotechnology, Dallas, TX, USA), anti-SOS-1 (1:500; sc-17793; Santa Cruz Biotechnology), anti-p-p38 MAPK (1:500; sc-166182, Santa Cruz Biotechnology), anti-pERK (1:500; sc-7383; Santa Cruz Biotechnology), p38 MAPK (1:500; sc-7972; Santa Cruz Biotechnology), ERK (1:500; sc-514302; Santa Cruz Biotechnology), β-catenin (1: 500; sc7963; Santa Cruz Biotechnology), anti-BID (1:500; sc-11423; Santa Cruz Biotechnology), anti-BAX (1:500; sc-20067; Santa Cruz Biotechnology), and anti-p53 (1:500; sc-126; Santa Cruz Biotechnology,) were the primary antibodies utilized.

Techniques: Expressing

List of antibodies used for Western blot (WB) and immunohistochemistry (IHC) assays.

Journal: Biomedicines

Article Title: ATT-Myc Transgenic Mouse Model and Gene Expression Identify Genotoxic and Non-Genotoxic Chemicals That Accelerating Liver Tumor Growth in Short-Term Toxicity

doi: 10.3390/biomedicines13030743

Figure Lengend Snippet: List of antibodies used for Western blot (WB) and immunohistochemistry (IHC) assays.

Article Snippet: P38 , Santa Cruz , 1:200 , Sc-7972.

Techniques: Western Blot, Immunohistochemistry